Can Pumpkin Save us of Doxorubicin Induced Cardiotoxicity?

Doxorubicin (DOX) is one of the drugs necessary for treatment 10 most common types cancer. The leading adverse effect limiting clinical use DOX cardiotoxicity. Given that literature data indicate a protective role carotenoids in doxorubicin-induced toxicity, our study we compared cardioprotective mixture pumpkin and commercially available antioxidant preparation. Animals were distributed 8 groups (Control - S; NADES N; Dox; Carotenoids Car; CardiofortIN CF; NADES-Doxorubicin N-Dox; Carotenoids-Doxorubicin Car-Dox; CardiofortIN-Doxorubicin CF-Dox). Histological sections stained with hematoxylin-eosin (HE) analyzed presence myocardial damage by doxorubicin score (DDS). From heart tissue homogenate determined intensity lipid peroxidation specific antioxidative enzyme activity (superoxide dismutase; catalase; glutathione S-transferase; peroxidase). In Car-DOX CF-DOX groups, significantly reduced to group. Pretreatment animals lesser extent led higher enzymes activity, Pretreated carotenoids, only 50 % had some degree damage, no extensive damage. pretreatment showed less effect. carotenoid extract, DDS significantly, so group has changes equivalent mild Although lowered values, still moderate level myocardium This vivo its findings extracted from may be promising agent against induced cardiotoxicity, at least part mediated through inhibition DOX-induced oxidative stress.